Functional maturation of the oligodendrocytes and myelin basic protein expression in the olfactory bulb of the mouse.
Brain Res
; 353(2): 277-82, 1985 Aug.
Article
em En
| MEDLINE
| ID: mdl-2412656
ABSTRACT
The timing of myelin basic protein (MBP) expression and myelin component synthesis by the oligodendrocytes of the olfactory bulb was investigated in the mouse. Immunostaining with an anti-MBP immunoserum and a radioimmunoassay determination of MBP allowed to study the timing of MBP deposition during the development in this structure. Immunostaining of dissociated cells with anti-MBP and anti-galactosylceramide (anti-GC) was used to determine the state of development when these markers become expressed by olfactory bulb oligodendrocytes. Investigations using dissociated cells showed that GC-positive oligodendrocytes are already detected 3 days after birth in the olfactory bulb of the mouse and MBP is expressed 4 days later. Myelinated fibers were not visible on cryostat sections of olfactory bulb before 8 days postnatal. This work has been initiated by observations on the timing of myelination of olfactory bulb oligodendrocytes in transplantation experiments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Cerebrosídeos
/
Oligodendroglia
/
Neuroglia
/
Proteína Básica da Mielina
/
Galactosilceramidas
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article