Uterine adenosarcomas: a dual-institution update on staging, prognosis and survival.
Gynecol Oncol
; 131(3): 634-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24135678
ABSTRACT
OBJECTIVE:
Uterine adenosarcomas (AS) are rare tumors thought to have a favorable prognosis. The aim of this study was to evaluate clinicopathological characteristics and treatment outcome in women with uterine AS.METHODS:
Patients with uterine AS were identified from the institutional databases at two regional cancer centers, Princess Margaret Hospital, Toronto and Vancouver General Hospital. All cases underwent specialist pathological review and were re-staged according to FIGO criteria (2009). Patient demographics, treatment data and outcomes were evaluated.RESULTS:
Between 1984 and 2010, 64 patients with confirmed AS were identified 30 exhibited sarcomatous overgrowth (AS+SO). 47 patients presented with stage I disease 27 IA and 18 IB. 57 of the 58 patients with known surgical management underwent hysterectomy 55 having bilateral salpingo-oophorectomy, 12 having lymph node dissection. 14 patients received adjuvant treatment 10 radiotherapy, 3 chemotherapy and 1 both. Sixteen of the 45 patients (35.6%) with follow-up recurred; median time to recurrence 21.2 months, range 2.1-87.8 months. Recurrence was associated with myometrial invasion (p=0.05). Two of the 10 women (20%) with AS+SO receiving adjuvant treatment recurred compared to 9 of the 14 (64%) who did not. One of the 5 women (20%) with stage IB disease who received adjuvant treatment recurred (20%) compared to 6 of the 7 (85.6%) who did not.CONCLUSIONS:
Long term surveillance is required given the variable time to recurrence. For those with AS+SO and myometrial invasion adjuvant treatment should be considered and further investigation of adjuvant strategies is warranted.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uterinas
/
Adenossarcoma
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
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Aged80
/
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article