Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA.

Kachko, Alla; Loesgen, Sandra; Shahzad-Ul-Hussan, Syed; Tan, Wendy; Zubkova, Iryna; Takeda, Kazuyo; Wells, Frances; Rubin, Steven; Bewley, Carole A; Major, Marian E

Kachko, Alla; Loesgen, Sandra; Shahzad-Ul-Hussan, Syed; Tan, Wendy; Zubkova, Iryna; Takeda, Kazuyo; Wells, Frances; Rubin, Steven; Bewley, Carole A; Major, Marian E.

Afiliação

Kachko A; Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA.
Loesgen S; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892, USA.
Shahzad-Ul-Hussan S; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892, USA.
Tan W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA.
Zubkova I; Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA.
Takeda K; Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA.
Wells F; Microscopy and Imaging Core Facility, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892. USA.
Rubin S; Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA.
Bewley CA; Laboratory of Method Development, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. USA.
Major ME; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892, USA.

Mol Pharm ; 10(12): 4590-4602, 2013 Dec 02.

Article em En | MEDLINE | ID: mdl-24152340

Assuntos

Antivirais/farmacologia; Proteínas de Bactérias/farmacologia; Proteínas de Transporte/farmacologia; Hepacivirus/efeitos dos fármacos; Lectinas de Ligação a Manose/farmacologia; Microcystis/metabolismo; Lectinas de Plantas/farmacologia; Linhagem Celular Tumoral; Cianobactérias/metabolismo; Glicoproteínas/metabolismo; Humanos; Proteínas Recombinantes/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas de Bactérias / Proteínas de Transporte / Hepacivirus / Lectinas de Ligação a Manose / Lectinas de Plantas / Microcystis Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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