[Current concepts of pathogenesis, clinical course and treatment of hepatitis delta (35 years since its discovery)].
Klin Med (Mosk)
; 91(5): 22-6, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24159781
ABSTRACT
Chronic HDV infection is a most serious and rapidly progressing hepatic disease with high risk of liver cirrhosis and hepato cellular carcinoma (HCC). Many aspects of its pathogenesis, virus biology and treatment remain unknown 35 years after the discovery of the disease. HDV is significantly different from HCV and HBV despite common route of infection. HDV as a satellite pathogen realizes its pathological action in an organism with compromised immune system that proved unable to eliminate HBEV. Hepatic lesions induced by HBV create favourable conditions for HDV propagation that causes rapid development of cirrhosis and its complications. The low efficacy of IFN-alpha therapy is due to the properties of HDV that inhibits the immune response. In most cases, decompensation and hepatic insufficiency determine prognosis of and mortality from HDV infection rather than HCC as in HBV and HCV.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatite D
/
Vírus Delta da Hepatite
/
Hepatite B
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Ru
Ano de publicação:
2013
Tipo de documento:
Article