Fecal and urinary NMR-based metabolomics unveil an aging signature in mice.

Calvani, Riccardo; Brasili, Elisa; Praticò, Giulia; Capuani, Giorgio; Tomassini, Alberta; Marini, Federico; Sciubba, Fabio; Finamore, Alberto; Roselli, Marianna; Marzetti, Emanuele; Miccheli, Alfredo

Calvani, Riccardo; Brasili, Elisa; Praticò, Giulia; Capuani, Giorgio; Tomassini, Alberta; Marini, Federico; Sciubba, Fabio; Finamore, Alberto; Roselli, Marianna; Marzetti, Emanuele; Miccheli, Alfredo.

Afiliação

Calvani R; Institute of Crystallography, National Research Council (CNR), Bari 70126, Italy.
Brasili E; National Institute of Research for Food and Nutrition (INRAN), Rome 00178, Italy.
Praticò G; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy.
Capuani G; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy.
Tomassini A; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy.
Marini F; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy.
Sciubba F; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy.
Finamore A; National Institute of Research for Food and Nutrition (INRAN), Rome 00178, Italy.
Roselli M; National Institute of Research for Food and Nutrition (INRAN), Rome 00178, Italy.
Marzetti E; Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome 00168, Italy.
Miccheli A; Institute of Crystallography, National Research Council (CNR), Bari 70126, Italy; Department of Chemistry, "Sapienza" University of Rome, Rome 00185, Italy. Electronic address: alfredo.miccheli@uniroma1.it.

Exp Gerontol ; 49: 5-11, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24184118

Assuntos

Envelhecimento/metabolismo; Fezes/química; Metaboloma/fisiologia; Envelhecimento/urina; Animais; Biomarcadores/metabolismo; Biomarcadores/urina; Espectroscopia de Ressonância Magnética/métodos; Masculino; Redes e Vias Metabólicas/fisiologia; Metabolômica/métodos; Camundongos; Camundongos Endogâmicos BALB C; Urinálise/métodos

Palavras-chave

(3-trimethylsilyl)propionic-(2,2,3,3-d4)-acid; 1-methylnicotinamide; 1MNA; AUROC; Area Under the ROC curve; DQ2; Discriminant Q2; LV; Latent Variable; MS; Metabolic footprint; Metabolic profiling; Metabolome; Methylnicotinamide; NMC; NMR; NNMT; Number of Misclassification; PBS; PLS-DA; Partial Least Squares-Discriminant Analysis; RP; Rank Product; S-adenosylmethionine; SAM; Senescence; TCA; THP; TSP; TammHorsfall protein; VIP; mass spectrometry; nicotinamide N-methyltransferase; nuclear magnetic resonance; phosphate buffered saline; tricarboxyl acid cycle; variable importance in projection

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Metaboloma / Fezes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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