Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.

Philbrook, Nicola A; Winn, Louise M

Philbrook, Nicola A; Winn, Louise M.

Afiliação

Philbrook NA; Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology Graduate Program, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Winn LM; Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology Graduate Program, Queen's University, Kingston, Ontario, Canada K7L 3N6; School of Environmental Studies, Queen's University, Kingston, Ontario, Canada K7L 3N6. Electronic address: winnl@queensu.ca.

Reprod Toxicol ; 43: 30-7, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24184564

Assuntos

Anticarcinógenos/farmacologia; Isotiocianatos/farmacologia; NAD(P)H Desidrogenase (Quinona)/metabolismo; Animais; Feminino; Glutamato-Cisteína Ligase/genética; Glutationa Transferase/genética; Heme Oxigenase-1/genética; Fígado/efeitos dos fármacos; Fígado/metabolismo; Troca Materno-Fetal; Proteínas de Membrana/genética; Camundongos; NAD(P)H Desidrogenase (Quinona)/genética; Gravidez; RNA Mensageiro/metabolismo; Sulfóxidos

Palavras-chave

GST; Gclc; HO-1; NQO1; Sulforaphane

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NAD(P)H Desidrogenase (Quinona) / Anticarcinógenos / Isotiocianatos Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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