Unexplained right atrial enlargement may be a sign of Holt-Oram syndrome in the fetus.
Ultrasound Obstet Gynecol
; 43(4): 475-6, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24185902
ABSTRACT
Two cases of ultrasound diagnosis of Holt-Oram syndrome are described. Both were characterized by significant right atrial enlargement that was not due to concurrent tricuspid regurgitation or other cardiac anomalies. In both cases the associated skeletal anomaly was subtle and barely visible using ultrasound. Interestingly, despite the fact that Holt-Oram syndrome is also called atriodigital dysplasia, unexplained right atrial enlargement has not been described in this context in the fetus before. When such a finding is detected, we believe a thorough search for upper limb abnormalities should be carried out and genetic testing for Holt-Oram syndrome should be discussed with the parents.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Múltiplas
/
Cardiomegalia
/
Deformidades Congênitas das Extremidades Inferiores
/
Deformidades Congênitas das Extremidades Superiores
/
Átrios do Coração
/
Cardiopatias Congênitas
/
Comunicação Interatrial
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article