Pulmonary anti-anaphylactic activity of clenbuterol tested on actively and passively sensitized guinea-pigs.
Eur J Pharmacol
; 119(3): 169-76, 1985 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-2419141
ABSTRACT
Clenbuterol, an adrenergic beta-mimetic agent free of cardiostimulant effects, prevents the release of histamine from isolated rat mast cells. We studied its anti-anaphylactic activity in guinea-pigs and compared it with that of isoprenaline. At doses inactive against the bronchoconstriction caused by 5HT, clenbuterol (3 micrograms/kg) and isoprenaline (0.1-0.3 micrograms/kg) prevented the bronchoconstriction due to 1 mg/kg ovalbumin infused into passively sensitized animals. Clenbuterol and isoprenaline (0.5-1 microM) inhibited by 40% the contractions of superfused parenchyma lung strips from actively sensitized animals, stimulated with 0.3, 1 and 10 micrograms of ovalbumin. When strips from passively sensitized animals were challenged in the organ bath, clenbuterol and isoprenaline (0.01 microM) reduced by 50% the contraction triggered by 10 micrograms/ml of ovalbumin. These concentrations of clenbuterol were ineffective against contractions caused by acetylcholine. Clenbuterol and isoprenaline (0.001-0.01 microM) inhibited the release of histamine and of thromboxane A2 triggered by ovalbumin (0.1, 1 and 10 micrograms) injected into isolated lungs from actively sensitized guinea-pigs indicating that the anti-anaphylactic properties of clenbuterol are independent from its smooth muscle relaxing activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clembuterol
/
Etanolaminas
/
Anafilaxia
/
Isoproterenol
/
Pulmão
/
Músculo Liso
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article