Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation.
Obstet Gynecol
; 51(3): 278-80, 1978 Mar.
Article
em En
| MEDLINE
| ID: mdl-24195
ABSTRACT
In in vitro studies it was found that, in the presence of added NADPH, the human placenta metabolizes progesterone to 20alpha-hydroxy-4-pregnen-3-one at increasing rates as pregnancy advances. A fivefold increase in 20alpha-hydroxysteroid oxidoreductase activity is observed in term placentas compared with the enzymic activity of placentas of 12 to 20 weeks' gestation (368 +/- 53 pmoles/mg protein/hr vs 71 +/- 8 pmoles/mg protein/hr). The 5alpha-reductase and 3beta-hydroxysteroid oxidoreductase activities were similar in placentas obtained from early and late human pregnancies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Progesterona
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article