Correlation between serum levels of small, dense low-density lipoprotein cholesterol and carotid stenosis in cerebral infarction patients >65 years of age.
Ann Vasc Surg
; 28(2): 375-80, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24200130
ABSTRACT
BACKGROUND:
We studied the relationship between serum levels of small, dense low-density lipoprotein cholesterol (sdLDL-C) and carotid stenosis in elderly patients with ischemic cerebral infarction.METHODS:
All patients >65 years of age with newly diagnosed ischemic cerebral infarction were enrolled. None received statins before enrollment. Patients were examined for carotid stenosis by ultrasound color Doppler, and serum sdLDL-C levels were measured using an automated method.RESULTS:
The 149 patients were distributed according to their carotid stenosis as without (n = 61) or with mild (n = 30), moderate (n = 34), or severe (n = 24) carotid stenosis. sdLDL-C levels increased significantly with increasing stenosis severity (0.54 ± 0.19, 0.71 ± 0.18, 0.98 ± 0.19, and 1.32 ± 0.17 mmol/L, respectively). Spearman rank correlation analysis revealed that sdLDL-C levels and degree of carotid stenosis were positively correlated (r = 0.411; P < 0.001). Male sex, body mass index, diabetes, hypertension, hyperlipidemia, drinking, smoking, and sdLDL-C levels were positively correlated with carotid stenosis. Logistic regression analysis revealed that sdLDL-C levels are an independent risk factor of carotid stenosis (P = 0.041).CONCLUSIONS:
sdLDL-C levels are positively correlated with the severity of carotid stenosis, and are an independent risk factor in elderly patients with ischemic cerebral infarction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infarto Cerebral
/
Estenose das Carótidas
/
LDL-Colesterol
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article