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AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet; Rickardson, Linda; Kultima, Hanna Göransson; de Wijn, Rik; Hovestad, Liesbeth; Fryknäs, Mårten; Öberg, Fredrik; Larsson, Rolf; Parrow, Vendela; Höglund, Martin.
Afiliação
  • Eriksson A; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden. Electronic address: anna.eriksson@medsci.uu.se.
  • Kalushkova A; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Jarvius M; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Hilhorst R; PamGene International B.V., 's-Hertogenbosch, The Netherlands.
  • Rickardson L; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Kultima HG; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
  • de Wijn R; PamGene International B.V., 's-Hertogenbosch, The Netherlands.
  • Hovestad L; PamGene International B.V., 's-Hertogenbosch, The Netherlands.
  • Fryknäs M; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Öberg F; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Larsson R; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
  • Parrow V; Akinion Pharmaceuticals AB, SE-17177 Stockholm, Sweden.
  • Höglund M; Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
Biochem Pharmacol ; 87(2): 284-91, 2014 Jan 15.
Article em En | MEDLINE | ID: mdl-24200998
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Proteínas Tirosina Quinases / Leucemia Mieloide Aguda / Regulação para Baixo / Genes myc / Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Indóis / Antineoplásicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Proteínas Tirosina Quinases / Leucemia Mieloide Aguda / Regulação para Baixo / Genes myc / Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Indóis / Antineoplásicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article