Assessment of serum 25-hydroxyvitamin d levels in children with atopic dermatitis: correlation with SCORAD index.
Dermatitis
; 24(6): 296-301, 2013.
Article
em En
| MEDLINE
| ID: mdl-24201460
ABSTRACT
BACKGROUND:
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an immunologic basis. It may have negative medical and social impacts on a patient and his family.OBJECTIVES:
To assess serum level of vitamin D among children with AD and determine its association with AD severity using the AD Scoring System Index. STUDYDESIGN:
A case-control study. PATIENTS ANDMETHODS:
Twenty-nine patients with AD in the age group between 2 and 12 years were enrolled in the study. The severity of the disease was determined by the AD scoring system. Thirty controls were recruited. Serum levels of 25-hydroxyvitamin D3 [25(OH)D3] were tested using commercial automated chemiluminescent microparticle immunoassay.RESULTS:
The mean value of vitamin D in children with AD was much lower than normal value, and there was a significant difference in the mean values of vitamin D between children with AD (5.4±1.9 ng/mL) and the controls (28.9±2.4 ng/mL). Serum 25(OH)D levels were found to be significantly higher in mild AD (14.6±3.5 ng/mL) compared with moderate (5.5±3.1 ng/mL) or severe AD (0.3±0.1 ng/mL); P<0.001.CONCLUSION:
Patients with AD have lower serum vitamin D levels than normal. Vitamin D deficiency might be related to the severity of AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Índice de Gravidade de Doença
/
Dermatite Atópica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article