Regioselective 1,4-trifluoromethylation of α,ß-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system.

ABSTRACT

Regioselective conjugate 1,4-trifluoromethylation of α,ß-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into ß-trifluoromethylated ketones in low to moderate yields.