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Validation of the revised international prognostic scoring system (IPSS-R) in patients with myelodysplastic syndrome: a multicenter study.
Neukirchen, Judith; Lauseker, Michael; Blum, Sabine; Giagounidis, Aristoteles; Lübbert, Michael; Martino, Samuela; Siragusa, Sergio; Schlenk, Richard F; Platzbecker, Uwe; Hofmann, Wolf-Karsten; Götze, Katharina; Palumbo, Giuseppe A; Magrin, Silvana; Kündgen, Andrea; Aul, Carlo; Hildebrandt, Barbara; Hasford, Joerg; Kobbe, Guido; Haas, Rainer; Germing, Ulrich.
Afiliação
  • Neukirchen J; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: Judith.Neukirchen@med.uni-duesseldorf.de.
  • Lauseker M; Institute for Medical Information Sciences, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
  • Blum S; Department of Hematology, University Lausanne, Switzerland.
  • Giagounidis A; Department of Hematology, Oncology and Clinical Immunology, St. Johannes Hospital, Duisburg, Germany.
  • Lübbert M; Department of Hematology and Oncology, Albert-Ludwigs-University, Freiburg, Germany.
  • Martino S; Department of Hematology, University of Palermo, Italy.
  • Siragusa S; Department of Hematology, University of Palermo, Italy.
  • Schlenk RF; Department of Internal Medicine III, University Hospital Ulm, Germany.
  • Platzbecker U; Department of Medicine 1, University Hospital Carl Gustav Carus, Dresden, Germany.
  • Hofmann WK; Department of Medicine III, University Hospital Mannheim, Germany.
  • Götze K; Department of Medicine III, Division for Hematology and Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany.
  • Palumbo GA; Department of Hematology, AOU "Policlinico - V. Emanuele", Catania, Italy.
  • Magrin S; Division of Hematology and BMT Unit, V. Cervello Hospital, Palermo, Italy.
  • Kündgen A; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Aul C; Department of Hematology, Oncology and Clinical Immunology, St. Johannes Hospital, Duisburg, Germany.
  • Hildebrandt B; Department of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany.
  • Hasford J; Institute for Medical Information Sciences, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
  • Kobbe G; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Haas R; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Germing U; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
Leuk Res ; 38(1): 57-64, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24238640
ABSTRACT
The revised IPSS (IPSS-R) was developed aiming at a better prognostication, taking into account patients treated with best supportive care. We herein validated this model on the basis of data from 1314 patients who received BSC only as well as patients who underwent induction chemotherapy (n=214) or allogeneic transplantation (n=167). We could demonstrate a clear distinction of the IPSS-R risk categories with regard to survival and risk of AML evolution in all patient cohorts. When comparing IPSS-R, IPSS, WHO prognostic scoring system (WPSS) and Duesseldorf score, the best results regarding the ability to predict survival were obtained by the IPSS-R.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide / Medição de Risco Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide / Medição de Risco Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article