Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.
Pflugers Arch
; 466(2): 201-6, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24240729
ABSTRACT
Cardiac myosin-binding protein C (cMyBP-C) research has been characterized by two waves. Initial interest was piqued by its discovery in 1973 as a contaminant of myosin preparations from skeletal muscle. The second wave started in 1995 by the discovery that mutations in the gene encoding cMyBP-C cause hypertrophic cardiomyopathy (HCM). In this review, we will address what is known of cMyBP-C's role as a regulator of contraction as well as its role in HCM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiomiopatia Hipertrófica
/
Proteínas de Transporte
/
Contração Miocárdica
/
Miocárdio
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article