Novel TiO2/PEGDA hybrid hydrogel prepared in situ on tumor cells for effective photodynamic therapy.
ACS Appl Mater Interfaces
; 5(23): 12317-22, 2013 Dec 11.
Article
em En
| MEDLINE
| ID: mdl-24245666
ABSTRACT
A novel inorganic/organic hybrid hydrogel system containing titanium dioxide (TiO2)/poly(ethylene glycol) double acrylates (PEGDA) was prepared by in situ photopolymerization on tumor cells for photodynamic therapy (PDT). TiO2 nanorods with diameter of â¼5 nm and length of â¼25 nm in this system presented dual functions, as effective photosensitizers for PDT and initiators for causing the in situ formation of hydrogel, under near-infrared (NIR) irradiation. The hybrid hydrogel retained the TiO2 around tumor cell to form a drug-loaded hydrogel shell. This resulted in a high concentration of singlet oxygen ((1)O2) under NIR irradiation, which induced apoptosis of tumor cell. Also, the hydrogel could reduce the side effects by preventing TiO2 from migrating to normal tissue. Furthermore, the TiO2 nanorods in this hydrogel shell were photochemically recyclable and could be reused in regular treatment. The outcomes of this study provide a new way to exploit multifunction of inorganic semiconductor nanomaterials for a variety of biomedical applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Polietilenoglicóis
/
Titânio
/
Hidrogéis
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article