Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors.

Bode, Saskia A; Wallbrecher, Rike; Brock, Roland; van Hest, Jan C M; Löwik, Dennis W P M

Bode, Saskia A; Wallbrecher, Rike; Brock, Roland; van Hest, Jan C M; Löwik, Dennis W P M.

Afiliação

Bode SA; Radboud University Nijmegen, Institute for Molecules and Materials, Bio-organic chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. d.lowik@science.ru.nl.

Chem Commun (Camb) ; 50(4): 415-7, 2014 Jan 14.

Article em En | MEDLINE | ID: mdl-24247922

ABSTRACT

ABSTRACT

A small library of oligoarginine peptides equipped with terminal cysteines was studied with respect to their cell-penetrating properties. The peptides themselves were inactive but gained the ability to enter cells upon extension of their sequence through disulfide bridge formation.

Assuntos

Peptídeos Penetradores de Células/química; Dissulfetos/química; Peptídeos Penetradores de Células/metabolismo; Citometria de Fluxo; Fluoresceína-5-Isotiocianato/química; Células HeLa; Humanos; Concentração de Íons de Hidrogênio; Microscopia Confocal

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dissulfetos / Peptídeos Penetradores de Células Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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