KBDOCK 2013: a spatial classification of 3D protein domain family interactions.
Nucleic Acids Res
; 42(Database issue): D389-95, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24271397
ABSTRACT
Comparing, classifying and modelling protein structural interactions can enrich our understanding of many biomolecular processes. This contribution describes Kbdock (http//kbdock.loria.fr/), a database system that combines the Pfam domain classification with coordinate data from the PDB to analyse and model 3D domain-domain interactions (DDIs). Kbdock can be queried using Pfam domain identifiers, protein sequences or 3D protein structures. For a given query domain or pair of domains, Kbdock retrieves and displays a non-redundant list of homologous DDIs or domain-peptide interactions in a common coordinate frame. Kbdock may also be used to search for and visualize interactions involving different, but structurally similar, Pfam families. Thus, structural DDI templates may be proposed even when there is little or no sequence similarity to the query domains.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bases de Dados de Proteínas
/
Domínios e Motivos de Interação entre Proteínas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article