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Myelination by transplanted fetal and neonatal oligodendrocytes in a dysmyelinating mutant.
Brain Res ; 378(1): 142-6, 1986 Jul 16.
Article em En | MEDLINE | ID: mdl-2427154
Demyelination is a major feature of CNS injury and disease, including multiple sclerosis. To examine the potential for myelination by transplanted oligodendrocytes, initially described by Gumpel et al., we have transplanted neonatal cortex of mice with normal myelin into a dysmyelinating mutant, the shiverer mouse. We have found that oligodendrocyte precursors mature and synthesize myelin following transplantation. Immunostaining with antibodies to myelin basic protein (MBP), neurofilament protein and glial fibrillary acidic protein, demonstrates myelination both within the graft and extending out into the host, axonal sprouting from the graft which parallels the MBP-reactivity, and minimal astrocytic proliferation in response to the transplant.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligodendroglia / Neuroglia / Doenças Desmielinizantes / Bainha de Mielina Limite: Animals Idioma: En Ano de publicação: 1986 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligodendroglia / Neuroglia / Doenças Desmielinizantes / Bainha de Mielina Limite: Animals Idioma: En Ano de publicação: 1986 Tipo de documento: Article