[Prognostic factors of upper tract urothelial carcinoma]. / Facteurs pronostiques des tumeurs de la voie excrétrice urinaire supérieure.
Prog Urol
; 23(16): 1382-8, 2013 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-24274942
ABSTRACT
INTRODUCTION:
Upper urinary tract urothelial carcinoma (UTUC) is a rare disease. Thus, little evidence-based data are available to guide clinical decision-making. The aim of the study was to provide an overview of the currently available prognostic factors for UTUC. MATERIAL ANDMETHODS:
A systematic literature search was conducted using the PubMed databases to identify original articles regarding prognostic factors in patients with UTUC.RESULTS:
We divided the prognostic factors for UTUC in four different categories clinical factors, preoperative characteristics, intraoperative/surgical factors and postoperative/pathologic factors. Prognostic factors described in order of importance are tumor stage and grade, lymph node involvement, a concomitant cis, age at the diagnostic, lymphovascular invasion, tumor architecture and necrosis, tumor location and multifocality, gender. The impact of obesity, smoking and other comorbidities (ECOG, ASA) on outcomes has been recently reported but needs to be validated. The endoscopic approach of distal ureter management during radical nephroureterectomy has been shown to be at higher risk of bladder recurrence.CONCLUSION:
The incorporation of such prognosticators into clinical prediction models might help to guide decision-making with regard to timing of surveillance, type of treatment, performance of lymphadenectomy, and consideration of neoadjuvant or adjuvant systemic therapies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ureterais
/
Carcinoma de Células de Transição
/
Recidiva Local de Neoplasia
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Fr
Ano de publicação:
2013
Tipo de documento:
Article