The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses.
J Virol
; 88(3): 1849-53, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24284320
ABSTRACT
Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Membrana Celular
/
Herpesvirus Humano 1
/
Internalização do Vírus
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Herpes Simples
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article