Biodistribution of rhenium cluster complex K4[Re6S8(CN)6] in the body of laboratory rats.
Bull Exp Biol Med
; 155(6): 741-4, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24288755
ABSTRACT
We studied the biodistribution of luminescent octahedral rhenium cluster complex K4[Re6S8(CN)6], a promising agent for photodynamic therapy. It was shown that rhenium complex [Re6S8(CN)6](4-)is mainly accumulated in the liver, the central organ of metabolism, and can be excreted by the kidneys. The cluster complex was also accumulated in the spleen in significant amount, which makes it a promising agent for creation of preparations for diagnostics and treatment of lymphoproliferative disorders. The mean lethal dose of the cluster complex was 0.38 g/kg.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fármacos Fotossensibilizantes
/
Complexos de Coordenação
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article