High throughput identification and quantification of 16 antipsychotics and 8 major metabolites in serum using ultra-high performance liquid chromatography-tandem mass spectrometry.

Patteet, Lisbeth; Maudens, Kristof E; Sabbe, Bernard; Morrens, Manuel; De Doncker, Mireille; Neels, Hugo

Patteet, Lisbeth; Maudens, Kristof E; Sabbe, Bernard; Morrens, Manuel; De Doncker, Mireille; Neels, Hugo.

Afiliação

Patteet L; Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Laboratory for TDM and Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerpen, Belgium. Electronic address: lisbeth.patteet@uantwerpen.be.
Maudens KE; Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Sabbe B; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Psychiatric Centre Sint-Norbertushuis, Stationstraat 22c, B-2570 Duffel, Belgium.
Morrens M; Laboratory for TDM and Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerpen, Belgium; Psychiatric Hospital Broeders Alexianen, Provinciesteenweg 408, B-2530 Boechout, Belgium.
De Doncker M; Laboratory for TDM and Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerpen, Belgium.
Neels H; Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Laboratory for TDM and Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerpen, Belgium.

Clin Chim Acta ; 429: 51-8, 2014 Feb 15.

Article em En | MEDLINE | ID: mdl-24291056

Assuntos

Antipsicóticos/sangue; Antipsicóticos/metabolismo; Análise Química do Sangue/métodos; Antipsicóticos/isolamento & purificação; Cromatografia Líquida de Alta Pressão; Humanos; Extração Líquido-Líquido; Reprodutibilidade dos Testes; Espectrometria de Massas em Tandem; Fatores de Tempo

Palavras-chave

7-hydroxy-N-desalkyl-quetiapine; 7-hydroxy-quetiapine; 7OH-NDA-QUE; 7OH-QUE; AGNP; AMI; AP; ARI; ASE; Antipsychotics; Arbeidsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie; BRO; CI; CLO; DARI; EMA; ER; ESI; European Medicines Agency; FDA; Food and Drug Administration; HAL; HILO; ILO; LC; LCMS/MS; LLE; LLOQ; LSUL; LUR; ME; MRM; MS; MTBE; Mass spectrometry; N-demethyl-clozapine; N-demethyl-olanzapine; NDM-CLO; NDM-OLA; Neuroleptics; OLA; PAL; PIP; QC; QUE; RHAL; RIS; RT; SER; SIL-IS; Therapeutic drug monitoring; UHPLCMS/MS; ZUC; amisulpride; antipsychotics; aripiprazole; asenapine; bromperidol; clozapine; confidence interval; dehydro-aripiprazole; electrospray ionization; extraction recovery; haloperidol; hydroxy-iloperidone; iloperidone; levosulpiride; liquid chromatography; liquid chromatographytandem mass spectrometry; liquidliquid extraction; lower limit of quantification; lurasidone; mass spectrometry; matrix effects; methyl tert-butyl ether; multiple-reaction monitoring; olanzapine; paliperidone; pipamperone; quality control; quetiapine; reduced haloperidol; retention time; risperidone; sertindole; stable isotope labeled internal standard; ultra-high performance liquid chromatographytandem mass spectrometry; zuclopenthixol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antipsicóticos / Análise Química do Sangue Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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