Effect of the surface chemistry of insulin fibrils on the aggregation rate.
Chemphyschem
; 15(1): 76-9, 2014 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-24302557
ABSTRACT
Structure transition cascade Insulin fibrils undergo a secondary structural transition-from the α-rich to the ß-rich form-upon progressively increasing the incubation time from 0.5 to ten hours. Atomic force microscopy measurements show that the fibril surface chemistry changes from hydrophilic to hydrophobic and the aggregation rate increases fivefold.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amiloide
/
Insulina
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article