Copper-catalyzed reduction of alkyl triflates and iodides: an efficient method for the deoxygenation of primary and secondary alcohols.
Angew Chem Int Ed Engl
; 53(3): 752-6, 2014 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-24307546
ABSTRACT
We describe an effective method for catalytic reduction of 1° alkyl sulfonates, and 1° and 2° iodides in the presence of a wide range of functional groups. This Cu-catalyzed reaction provides a means for the effective deoxygenation of alcohols, as demonstrated by the highly selective reduction of 1° alcohols using a triflation/reduction sequence. A preliminary study of the reaction mechanism suggests that the reduction does not involve free-radical intermediates.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcanossulfonatos
/
Cobre
/
Álcoois
/
Iodetos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article