A versatile RNA vector for delivery of coding and noncoding RNAs.
J Virol
; 88(4): 2333-6, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24307584
The discovery that RNA viruses, lacking any DNA intermediate, can be engineered to express both coding and noncoding RNAs suggests that this platform may have therapeutic value as a delivery vehicle. Here we illustrate that a self-replicating, noninfectious RNA, modeled on influenza virus, provides one such example of a versatile in vivo delivery system for silencing and/or expressing a desired RNA for therapeutic purposes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus de RNA
/
Transdução Genética
/
Engenharia Genética
/
Interferência de RNA
/
Vetores Genéticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article