Lactose as a "Trojan horse" for quantum dot cell transport.
Angew Chem Int Ed Engl
; 53(3): 810-4, 2014 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-24311369
ABSTRACT
A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pontos Quânticos
/
Lactose
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article