Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model.

Sharma, Horrick; Santra, Soumava; Debnath, Joy; Antonio, Tamara; Reith, Maarten; Dutta, Aloke

Sharma, Horrick; Santra, Soumava; Debnath, Joy; Antonio, Tamara; Reith, Maarten; Dutta, Aloke.

Afiliação

Sharma H; Wayne State University, Department of Pharmaceutical Sciences, Applebaum College of Pharmacy & Health Sciences, Rm# 3128, Detroit, MI 48202, United States.
Santra S; Wayne State University, Department of Pharmaceutical Sciences, Applebaum College of Pharmacy & Health Sciences, Rm# 3128, Detroit, MI 48202, United States.
Debnath J; Wayne State University, Department of Pharmaceutical Sciences, Applebaum College of Pharmacy & Health Sciences, Rm# 3128, Detroit, MI 48202, United States.
Antonio T; New York University, Department of Psychiatry, New York, NY 10016, United States.
Reith M; New York University, Department of Psychiatry, New York, NY 10016, United States; New York University, Department of Pharmacology, New York, NY 10016, United States.
Dutta A; Wayne State University, Department of Pharmaceutical Sciences, Applebaum College of Pharmacy & Health Sciences, Rm# 3128, Detroit, MI 48202, United States. Electronic address: adutta@wayne.edu.

Bioorg Med Chem ; 22(1): 311-24, 2014 Jan 01.

Article em En | MEDLINE | ID: mdl-24315194

Assuntos

Antidepressivos/química; Antidepressivos/farmacologia; Depressão/imunologia; Inibidores da Captação de Neurotransmissores/química; Piranos/química; Piranos/farmacologia; Antidepressivos/metabolismo; Biomimética; Encéfalo/metabolismo; Biologia Computacional; Depressão/tratamento farmacológico; Proteínas de Membrana Transportadoras/metabolismo; Conformação Molecular; Inibidores da Captação de Neurotransmissores/farmacologia; Piranos/metabolismo; Estereoisomerismo; Relação Estrutura-Atividade

Palavras-chave

Antidepressants; Asymmetric synthesis; Computational analysis; DAT; Depression; MAO; NET; Pharmacophore model; SAR; SERT; SNRI; SSRI; TCA; TUI; Triple uptake inhibitors; dopamine transporter; monoamine oxidase inhibitors; norepinephrine transporters; selective serotonin reuptake inhibitors; serotonin transporter; serotonin/norepinephrine reuptake inhibitors; structureactivity relationship; tricyclic antidepressants; triple uptake inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Inibidores da Captação de Neurotransmissores / Depressão / Antidepressivos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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