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Prevention of defects of axonal transport in experimental diabetes by aldose reductase inhibitors.
Drugs ; 32 Suppl 2: 15-8, 1986.
Article em En | MEDLINE | ID: mdl-2431858
ABSTRACT
Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was 'real' not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desidrogenase do Álcool de Açúcar / Transporte Axonal / Aldeído Redutase / Neuropatias Diabéticas Limite: Animals Idioma: En Ano de publicação: 1986 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desidrogenase do Álcool de Açúcar / Transporte Axonal / Aldeído Redutase / Neuropatias Diabéticas Limite: Animals Idioma: En Ano de publicação: 1986 Tipo de documento: Article