[The relationship between hyperuricemia and contrast-induced nephropathy in patients with chronic kidney disease undergoing percutaneous coronary intervention].
Zhonghua Xin Xue Guan Bing Za Zhi
; 41(9): 740-3, 2013 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-24331800
ABSTRACT
OBJECTIVE:
To investigate the relationship between hyperuricemia and contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI).METHODS:
A total of 446 consecutive patients with CKD undergoing PCI in Guangdong general hospital were enrolled in this study. Patients were divided into hyperuricemic group (n = 205) and normouricemic group (n = 241).Hyperuricemia was defined as serum uric acid > 420 µmol/L for male, > 357 µmol/L for female. CIN was defined as ≥ 44.2 µmol/L or ≥ 25% increase from baseline Serum creatinine within 48-72 hours after contrast medium exposure, and that was not attributable to other causes.In hospital incidences of CIN and the major adverse cardiac events were compared between the two groups. The relationship between the incidence of CIN and hyperuricemia was evaluated by multivariate logistic regression analysis.RESULTS:
CIN occurred in 16.6% (74/446) of patients, and incidence of CIN was significantly higher in the hyperuricemic group than in the normouricemic group [23.9% (49/446) vs. 10.4% (25/446) , P = 0.000]. Patients who developed CIN had higher in hospital mortality [14.9% (11/74) vs. 1.3% (5/372), P = 0.000]. Need for renal replacement therapy, acute heart failure, intra-aortic balloon pump use and the hypotension after PCI were significantly higher in the hyperuricemic group compared with normouricemic group (P < 0.01 or P < 0.05) . Multivariate analysis indicates that hyperuricemia (OR = 1.9, 95%CI1.1-3.5, P = 0.037), age > 75 years (OR = 3.2, 95%CI1.8-5.7, P = 0.000) , emergent PCI (OR = 2.9, 95%CI1.6-5.1, P = 0.000) and anemia (OR = 2.1, 95%CI1.2-3.8, P = 0.012) were predictors of CIN in patients with CKD.CONCLUSION:
Hyperuricemia is the independent risk predictor of CIN in patients with CKD undergoing PCI.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meios de Contraste
/
Hiperuricemia
/
Insuficiência Renal Crônica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article