Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism.

Bouchareb, Rihab; Boulanger, Marie-Chloé; Fournier, Dominique; Pibarot, Philippe; Messaddeq, Younès; Mathieu, Patrick

Bouchareb, Rihab; Boulanger, Marie-Chloé; Fournier, Dominique; Pibarot, Philippe; Messaddeq, Younès; Mathieu, Patrick.

Afiliação

Bouchareb R; Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.
Boulanger MC; Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.
Fournier D; Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.
Pibarot P; Department of Medicine, Laval University, Québec, Canada.
Messaddeq Y; Department of Physics, Laval University, Québec, Canada.
Mathieu P; Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address: patrick.mathieu@chg.ulaval.ca.

J Mol Cell Cardiol ; 67: 49-59, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24368096

Assuntos

Valva Aórtica/patologia; Micropartículas Derivadas de Células/metabolismo; Estresse Mecânico; Quinases Associadas a rho/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Calcinose/fisiopatologia; Membrana Celular/metabolismo; Células Cultivadas; Citometria de Fluxo; Regulação da Expressão Gênica; Humanos; Minerais/metabolismo; Diester Fosfórico Hidrolases/genética; Pirofosfatases/genética

Palavras-chave

Calcific aortic valve disease; ENPP1; Mineralized microparticles; RhoA; Strain; Valve interstitial cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valva Aórtica / Estresse Mecânico / Proteína rhoA de Ligação ao GTP / Quinases Associadas a rho / Micropartículas Derivadas de Células Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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