Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity.
Bioorg Med Chem
; 22(2): 728-37, 2014 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-24369840
ABSTRACT
A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5µmol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1µmol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs ≥1.95µmol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82µmol/L, but there is no direct correlation with MICs for mycobacteria.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organofosfatos
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Salicilanilidas
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Bactérias
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Fungos
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Antibacterianos
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Antifúngicos
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article