Thrombin promotes matrix metalloproteinase-13 expression through the PKCÎ´ c-Src/EGFR/PI3K/Akt/AP-1 signaling pathway in human chondrocytes.

Huang, Chun-Yin; Lin, Hsiu-Jung; Chen, Hsin-Shui; Cheng, Shi-Yann; Hsu, Horng-Chaung; Tang, Chih-Hsin

Huang, Chun-Yin; Lin, Hsiu-Jung; Chen, Hsin-Shui; Cheng, Shi-Yann; Hsu, Horng-Chaung; Tang, Chih-Hsin.

Afiliação

Huang CY; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan ; Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yunlin County, Taiwan ; School of Medicine, China Medical University, Taichung, Taiwan.
Lin HJ; Department of Nursing, China Medical University Beigang Hospital, Yunlin County, Taiwan.
Chen HS; School of Medicine, China Medical University, Taichung, Taiwan ; Department of Physical Medicine and Rehabilitation, China Medical University Beigang Hospital, Yunlin County, Taiwan.
Cheng SY; School of Medicine, China Medical University, Taichung, Taiwan ; Department of Obstetrics and Gynecology, China Medical University Beigang Hospital, Yunlin County, Taiwan.
Hsu HC; School of Medicine, China Medical University, Taichung, Taiwan ; Department of Orthopaedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Tang CH; School of Medicine, China Medical University, Taichung, Taiwan ; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan ; Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan.

Mediators Inflamm ; 2013: 326041, 2013.

Article em En | MEDLINE | ID: mdl-24385683

Assuntos

Condrócitos/enzimologia; Metaloproteinase 13 da Matriz/genética; Transdução de Sinais; Trombina/farmacologia; Artrite Reumatoide/etiologia; Proteína Tirosina Quinase CSK; Células Cultivadas; Receptores ErbB/fisiologia; Humanos; Osteoartrite/etiologia; Fosfatidilinositol 3-Quinases/fisiologia; Proteína Quinase C-delta/fisiologia; Proteínas Proto-Oncogênicas c-akt/fisiologia; RNA Mensageiro/análise; Receptor PAR-1/fisiologia; Transdução de Sinais/fisiologia; Fator de Transcrição AP-1/fisiologia; Quinases da Família src/fisiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombina / Transdução de Sinais / Condrócitos / Metaloproteinase 13 da Matriz Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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