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Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.
Leung, Lisa; Radulovich, Nikolina; Zhu, Chang-Qi; Wang, Dennis; To, Christine; Ibrahimov, Emin; Tsao, Ming-Sound.
Afiliação
  • Leung L; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada ; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Radulovich N; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada ; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Zhu CQ; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Wang D; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • To C; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Ibrahimov E; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Tsao MS; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada ; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto
PLoS One ; 8(12): e84366, 2013.
Article em En | MEDLINE | ID: mdl-24386371
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ductos Pancreáticos / Transdução de Sinais / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas / Proteínas ras / Carcinoma Ductal Pancreático / Células Epiteliais / Proteína Smad4 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ductos Pancreáticos / Transdução de Sinais / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas / Proteínas ras / Carcinoma Ductal Pancreático / Células Epiteliais / Proteína Smad4 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article