Nonablative fractional laser as a tool to facilitate skin penetration of 5-aminolaevulinic acid with minimal skin disruption: a preliminary study.
Br J Dermatol
; 170(6): 1336-40, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24386881
ABSTRACT
BACKGROUND:
Effective penetration of a photosensitizer is an essential step in photodynamic therapy (PDT). There have been trials of several methods, including laser treatment, to facilitate prompt and sufficiently deep transdermal drug delivery.OBJECTIVE:
To evaluate the effects of nonablative fractional laser pretreatment on 5-aminolaevulinic acid (ALA) penetration of the skin.METHODS:
Twelve treatment areas (1 × 1 cm(2)) on the backs of 10 healthy male subjects were mapped. Test areas received laser treatment followed by incubation with ALA. Laser treatment was performed with a 1550 nm fractional erbium glass laser, and the laser energy was set to 20 or 50 mJ with a spot density of 50 cm(-2). ALA incubation time was 30, 60 or 180 min. Porphyrin fluorescence was measured.RESULTS:
Sites pretreated with nonablative fractional laser showed significantly increased porphyrin fluorescence compared with nonpretreated areas. Laser energy strength and ALA incubation time were positively correlated with ALA absorption.CONCLUSIONS:
Nonablative fractional laser treatment effectively enhanced ALA skin penetration. Pretreatment with a nonablative fractional laser can be used for ALA-PDT to achieve higher ALA uptake and shortened ALA incubation times with minimal skin barrier disruption compared with ablative laser.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Pele
/
Fármacos Fotossensibilizantes
/
Terapia a Laser
/
Ácido Aminolevulínico
Tipo de estudo:
Evaluation_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article