New natural products as new leads for antibacterial drug discovery.

Brown, Dean G; Lister, Troy; May-Dracka, Tricia L

Brown, Dean G; Lister, Troy; May-Dracka, Tricia L.

Afiliação

Brown DG; AstraZeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA 02451, United States. Electronic address: dean.brown@astrazeneca.com.
Lister T; AstraZeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA 02451, United States.
May-Dracka TL; AstraZeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA 02451, United States.

Bioorg Med Chem Lett ; 24(2): 413-8, 2014 Jan 15.

Article em En | MEDLINE | ID: mdl-24388805

ABSTRACT

ABSTRACT

Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes and the mechanisms by which they work.

Assuntos

Antibacterianos/química; Produtos Biológicos/química; Descoberta de Drogas/tendências; Animais; Cristalografia por Raios X; Descoberta de Drogas/métodos; Humanos

Palavras-chave

Antibacterial; Antimicrobial; Natural products

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Descoberta de Drogas / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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