Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa.
J Nat Prod
; 77(1): 22-8, 2014 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-24400834
ABSTRACT
Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 µM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Terpenos
/
Hepacivirus
/
Euphorbiaceae
/
Diterpenos
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article