GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.

Schaer, David A; Budhu, Sadna; Liu, Cailian; Bryson, Campbell; Malandro, Nicole; Cohen, Adam; Zhong, Hong; Yang, Xia; Houghton, Alan N; Merghoub, Taha; Wolchok, Jedd D

Schaer, David A; Budhu, Sadna; Liu, Cailian; Bryson, Campbell; Malandro, Nicole; Cohen, Adam; Zhong, Hong; Yang, Xia; Houghton, Alan N; Merghoub, Taha; Wolchok, Jedd D.

Afiliação

Schaer DA; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Budhu S; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Liu C; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Bryson C; Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, New York, NY.
Malandro N; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY ; Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, New York, NY.
Cohen A; Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA.
Zhong H; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Yang X; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Houghton AN; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Merghoub T; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
Wolchok JD; Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY ; Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, New York, NY ; Ludwig Center for Cancer Immu

Cancer Immunol Res ; 1(5): 320-31, 2013 Nov.

Article em En | MEDLINE | ID: mdl-24416730

Assuntos

Proteína Relacionada a TNFR Induzida por Glucocorticoide/imunologia; Linfócitos T Reguladores/imunologia; Animais; Linhagem Celular Tumoral; Proteína Relacionada a TNFR Induzida por Glucocorticoide/agonistas; Proteína Relacionada a TNFR Induzida por Glucocorticoide/metabolismo; Tolerância Imunológica; Melanoma Experimental/imunologia; Melanoma Experimental/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Linfócitos T Reguladores/metabolismo

Palavras-chave

Foxp3; GITR; Helios; Intra-tumor Immune suppression; Regulatory T cell Lineage Stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Proteína Relacionada a TNFR Induzida por Glucocorticoide Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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