DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis.
J Cell Physiol
; 229(10): 1330-5, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24420845
ABSTRACT
As a member of the mononuclear phagocyte system, osteoclasts (OC) absorb the bone matrix and participate in bone modeling by keeping a balance with osteoblasts (OB) and stromal cells. Mature OC derive from the fusion of mononuclear osteoclasts (mOC) and the fusion is considered as the indispensable process for the osteoclastogenesis and absorbing activity of OC. DC-STAMP (dendritic cell-specific transmembrane protein) has been validated playing a key role in the fusion of mOC. DC-STAMP is mainly expressed in OC, macrophages and dendritic cells (DC). While DC-STAMP was discovered in DC, more attentions have been paid to DC-STAMP in OC in this decade. This review will mainly focus on the function of DC-STAMP in OC. Studies on DC-STAMP in DC may also provide new sight for the study of DC-STAMP in OC. Since the function of DC-STAMP is still poorly understood and few studies have been implemented for illustration, many issues are still unknown and need to be revealed. We will also discuss these questions in this review.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoclastos
/
Reabsorção Óssea
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Proteínas Adaptadoras de Transdução de Sinal
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Proteínas de Membrana
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article