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Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors.
Lin, Songwen; Han, Fangbin; Liu, Peng; Tao, Jing; Zhong, Xuechao; Liu, Xiujie; Yi, Chongqin; Xu, Heng.
Afiliação
  • Lin S; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Han F; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Liu P; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Tao J; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Zhong X; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Liu X; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China.
  • Yi C; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China. Electronic address: yichongqin@founder.com.
  • Xu H; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No. 29 Life Science Park Road, Changping District, Beijing 102206, PR China. Electronic address: xuheng@pkucare-pharm.com.
Bioorg Med Chem Lett ; 24(3): 790-3, 2014 Feb 01.
Article em En | MEDLINE | ID: mdl-24433860
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Naftiridinas Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Naftiridinas Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article