RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress.

Kim, Su-Hyeon; Park, Eun-Ran; Joo, Hyun-Yoo; Shen, Yan Nan; Hong, Sung Hee; Kim, Chun Ho; Singh, Rachana; Lee, Kee-Ho; Shin, Hyun-Jin

Kim, Su-Hyeon; Park, Eun-Ran; Joo, Hyun-Yoo; Shen, Yan Nan; Hong, Sung Hee; Kim, Chun Ho; Singh, Rachana; Lee, Kee-Ho; Shin, Hyun-Jin.

Afiliação

Kim SH; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Park ER; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Joo HY; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Shen YN; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Hong SH; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Kim CH; Division of Radiation Effect, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Singh R; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
Lee KH; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea. Electronic address: khlee@kirams.re.kr.
Shin HJ; Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea. Electronic address: hjshin@kcch.re.kr.

Cancer Lett ; 346(2): 249-56, 2014 May 01.

Article em En | MEDLINE | ID: mdl-24434653

Assuntos

Proteína Quinase CDC2/metabolismo; Centrossomo/fisiologia; Replicação do DNA/fisiologia; Proteínas Quinases/metabolismo; Proteínas Supressoras de Tumor/genética; Proteína Quinase CDC2/genética; Linhagem Celular Tumoral; Centrossomo/metabolismo; Quinase 1 do Ponto de Checagem; Ciclina A/metabolismo; Ciclina B/metabolismo; Dano ao DNA; Replicação do DNA/genética; Técnicas de Silenciamento de Genes; Células HeLa; Humanos; Proteínas Quinases/genética; RNA Interferente Pequeno/administração & dosagem; RNA Interferente Pequeno/genética; Ribonucleosídeo Difosfato Redutase; Transdução de Sinais; Transfecção; Proteínas Supressoras de Tumor/deficiência; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

Centrosome integrity; DNA damage; RRM1; Replication fork stalling; Tumor suppressor; Tumorigenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Proteína Quinase CDC2 / Centrossomo / Proteínas Supressoras de Tumor / Replicação do DNA Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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