Diastereoselective three-component reactions of chiral nickel(II) glycinate for convenient synthesis of novel α-amino-ß-substituted-γ,γ-disubstituted butyric acids.

ABSTRACT

The convenient, high yielding and diastereoselective synthesis of α-amino-ß-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-ß-substituted-γ,γ-disubstituted butyric acid derivatives.