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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Namoto, Kenji; Sirockin, Finton; Ostermann, Nils; Gessier, Francois; Flohr, Stefanie; Sedrani, Richard; Gerhartz, Bernd; Trappe, Jörg; Hassiepen, Ulrich; Duttaroy, Alokesh; Ferreira, Suzie; Sutton, Jon M; Clark, David E; Fenton, Garry; Beswick, Mandy; Baeschlin, Daniel K.
Afiliação
  • Namoto K; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland. Electronic address: kenji.namoto@novartis.com.
  • Sirockin F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Ostermann N; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Gessier F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Flohr S; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Sedrani R; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Gerhartz B; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Trappe J; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Hassiepen U; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
  • Duttaroy A; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Ferreira S; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Sutton JM; Argenta Discovery 2009 Ltd, Harlow CM19 5TR, UK.
  • Clark DE; Argenta Discovery 2009 Ltd, Harlow CM19 5TR, UK.
  • Fenton G; Argenta Discovery 2009 Ltd, Harlow CM19 5TR, UK.
  • Beswick M; Argenta Discovery 2009 Ltd, Harlow CM19 5TR, UK.
  • Baeschlin DK; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
Bioorg Med Chem Lett ; 24(3): 731-6, 2014 Feb 01.
Article em En | MEDLINE | ID: mdl-24439847
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptidil Peptidase 4 / Inibidores da Dipeptidil Peptidase IV / Descoberta de Drogas / Metilaminas Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptidil Peptidase 4 / Inibidores da Dipeptidil Peptidase IV / Descoberta de Drogas / Metilaminas Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article