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Genome of the human hookworm Necator americanus.
Tang, Yat T; Gao, Xin; Rosa, Bruce A; Abubucker, Sahar; Hallsworth-Pepin, Kymberlie; Martin, John; Tyagi, Rahul; Heizer, Esley; Zhang, Xu; Bhonagiri-Palsikar, Veena; Minx, Patrick; Warren, Wesley C; Wang, Qi; Zhan, Bin; Hotez, Peter J; Sternberg, Paul W; Dougall, Annette; Gaze, Soraya Torres; Mulvenna, Jason; Sotillo, Javier; Ranganathan, Shoba; Rabelo, Elida M; Wilson, Richard W; Felgner, Philip L; Bethony, Jeffrey; Hawdon, John M; Gasser, Robin B; Loukas, Alex; Mitreva, Makedonka.
Afiliação
  • Tang YT; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Gao X; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Rosa BA; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Abubucker S; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Hallsworth-Pepin K; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Martin J; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Tyagi R; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Heizer E; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Zhang X; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Bhonagiri-Palsikar V; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Minx P; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Warren WC; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Wang Q; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Zhan B; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Hotez PJ; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • Sternberg PW; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas, USA.
  • Dougall A; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • Gaze ST; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas, USA.
  • Mulvenna J; Division of Biology, California Institute of Technology, Pasadena, California, USA.
  • Sotillo J; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
  • Ranganathan S; Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, James Cook University, Cairns, QLD, Australia.
  • Rabelo EM; Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, James Cook University, Cairns, QLD, Australia.
  • Wilson RW; Queensland Institute of Medical Research, Brisbane, QLD, Australia.
  • Felgner PL; Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, James Cook University, Cairns, QLD, Australia.
  • Bethony J; Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Hawdon JM; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Gasser RB; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
  • Loukas A; The Genome Institute at Washington University, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Mitreva M; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA.
Nat Genet ; 46(3): 261-269, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24441737
The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Necator americanus / Genoma Helmíntico Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Necator americanus / Genoma Helmíntico Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Ano de publicação: 2014 Tipo de documento: Article