Synthesis and antinociception activity of new substituted phenothiazines and ethylenediamines as antihistaminic drugs.
Drug Res (Stuttg)
; 64(11): 584-90, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24446204
ABSTRACT
Antihistamines play an important role in medicine when it comes to relieving seasonal or non-seasonal rhinitis, the common cold, and itching. They have also shown many various combinations of pharmacological properties such as anti-inflammatory and analgesic activities. Phenothiazines and ethylenediamines are 2 important classes of antihistamines with analgesic activities in addition to other pharmacological effects. In this study, some new derivatives of these compounds (V-IX) were synthesized and their antinociceptive behaviors were examined by pharmacological tests. The results indicated that new analogue with methyl groups produced a better analgesic activity than chlorine atoms but less than III (without any substitutions) in ethylenediamine class. Also in phenothiazine class, adding pyrimidine and pyridine substituted showed the better analgesic activity compared to other groups. Moreover, the analgesic activities proved that dimethylamine is the best group in amino alkyl side chain of these molecules relative to the substituted piperazines in new analogues.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenotiazinas
/
Etilenodiaminas
/
Antagonistas dos Receptores Histamínicos
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article