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Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease.
Kwon, Young-Man; Hwang, Hye Suk; Lee, Jong Seok; Ko, Eun-Ju; Yoo, Si-Eun; Kim, Min-Chul; Lee, Yu-Na; Kim, Ki-Hye; Song, Jae-Min; Lee, Sujin; Moore, Martin L; Kang, Sang-Moo.
Afiliação
  • Kwon YM; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Hwang HS; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Lee JS; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Ko EJ; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Yoo SE; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Kim MC; Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, South Korea.
  • Lee YN; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Kim KH; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
  • Song JM; Department of Global Medical Science, Sungshin Women's University, Seoul, South Korea.
  • Lee S; Department of Pediatrics, Emory University, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Moore ML; Department of Pediatrics, Emory University, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Kang SM; Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA. Electronic address: skang24@gsu.edu.
Antiviral Res ; 104: 1-6, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24462695
ABSTRACT
Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Sinciciais Respiratórios / Vacinas Virais / Vacinas de Produtos Inativados / Infecções por Vírus Respiratório Sincicial / Imunidade Materno-Adquirida / Anticorpos Antivirais Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Sinciciais Respiratórios / Vacinas Virais / Vacinas de Produtos Inativados / Infecções por Vírus Respiratório Sincicial / Imunidade Materno-Adquirida / Anticorpos Antivirais Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article