Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents.
J Neurosci Res
; 92(4): 446-54, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24464856
ABSTRACT
Glucagon-like peptide-1 (GLP-1) is derived from the processing of proglucagon in intestinal L-cells and releases insulin from pancreatic ß-cells as an incretin. The GLP-1 receptor has been proposed as a possible therapeutic target for the treatment of Alzheimer's disease, in which neuroinflammation is critical in the pathogenesis. The present study investigates whether GLP-1 (7-36) amide, an active fragment of GLP-1, protected against synaptic impairments induced by inflammation-related injurious agents (lipopolysaccharide [LPS], interleukin-1ß [IL-1ß], and H2 O2). In the Y-maze test, LPS (10 µg/mouse, i.c.v) significantly decreased the percentage alternation. Pretreatment with GLP-1 (7-36) amide (0.09-0.9 nmol/mouse, i.c.v.) prevented an impairment in spontaneous alternation performance. Pretreatment with LPS (10 µg/ml, 2 hr) impaired LTP induction but not paired-pulse facilitation in the CA1 region of rat hippocampal slices. This impairment was prevented by cotreatment with GLP-1 (7-36) amide (50 nM). IL-1ß (0.57 nM) or H2 O2 (50 µM) also impaired LTP induction. This impairment was prevented by GLP-1 (7-36) amide (50 nM). These results suggest that GLP-1 (7-36) amide improves the synaptic impairments induced by inflammation-related injurious agents in the CA1 region of the hippocampus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Potenciação de Longa Duração
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Encefalite
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Peptídeo 1 Semelhante ao Glucagon
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Deficiências da Aprendizagem
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article