Adjuvant aqueous ozone in the treatment of bisphosphonate induced necrosis of the jaws: report of two cases and long-term follow-up.
Minerva Stomatol
; 63(1-2): 35-41, 2014.
Article
em En
| MEDLINE
| ID: mdl-24487948
ABSTRACT
Bisphosphonate induced necrosis of the jaws (BONJ) does not have a unique protocol of treatment and many therapeutic approaches have been arising in oral medicine with debatable results. A male and a female attended the University Oral Surgery Clinic presenting oral bone lesions induced by intravenous and oral bisphosphonates respectively as complications of dental extraction. Treatment included daily mouthwashes and weekly intra oral irrigations with 4 mg/L of aqueous-ozone, antibiotic therapy and sequential superficial debridment for sequestrectomies. Long-standing follow-ups showed complete mucosa covering of exposed bone area and resolution of purulent secretion. Antibacterial and antifungal properties of aqueous ozone may have played important roles in the treatment. The outcome measured intra oral examination and panoramic radiographs of the affected bone. The application of aqueous ozone daily mouthwashes and weekly professional irrigation were safe; free from adverse effects, easily of handling and worked as an important adjuvant therapeutic strategy for the treatment of BONJ.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ozônio
/
Quimioterapia Adjuvante
/
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos
/
Anti-Infecciosos
Tipo de estudo:
Guideline
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article