The role of TNF-α G-308A promoter polymorphism in glycemic control in Type 2 diabetes patients.
J Endocrinol Invest
; 37(2): 113-8, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24497209
ABSTRACT
BACKGROUND:
TNF-α polymorphisms were shown to be associated with insulin resistance and diabetes development and complications.AIM:
To investigate the association between glycemic control in Type 2 diabetes patients and TNF-α G-308A single nucleotide polymorphism (SNP).METHODS:
This was a cross-sectional observational study, where diabetes patients from both genders (170 male and 185 female) were enrolled in the study. Patients were divided into two groups good glycemic control (n = 158) and poor glycemic control (n = 197). Genotyping of TNF-α G-308A SNP was carried out using restriction fragment length polymorphisms-polymerase chain reaction.RESULTS:
The results showed that TNF-α G-308A SNP is strongly associated with glycemic control in type 2 diabetes patients. Patients with the AA and AG genotypes had better glycemic control than those with GG genotype (P < 0.01). Other parameters that impacted glycemic control include duration of the disease (P < 0.01) and response to insulin therapy (P < 0.01). However, no contribution for gender or statins use to glycemic control was observed (P > 0.05).CONCLUSION:
TNF-α G-308A SNP might modulate glycemic control among type 2 diabetes patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Regiões Promotoras Genéticas
/
Fator de Necrose Tumoral alfa
/
Polimorfismo de Nucleotídeo Único
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article