Crossover patterning by the beam-film model: analysis and implications.
PLoS Genet
; 10(1): e1004042, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24497834
ABSTRACT
Crossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena CO homeostasis, the fact that the level of zero-CO bivalents can be low (the "obligatory CO"), and the occurrence of non-interfering COs. Relationships to other models are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos
/
Troca Genética
/
Meiose
/
Modelos Genéticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article